Differences between using acetonitrile and methanol for. Advancebio peptide chromatography columns with acetonitrile and water less than 10ml section 2. Acetonitrile cas no 75058 material safety data sheet. Its reaction with cyanogen chloride affords malononitrile. Acetonitrile metabolizes into cyanide over 2 to 8 hours, so symptoms or signs of toxicity may be delayed after significant exposures. Acetonitrile revision date 17january2018 stability stable under normal conditions. Acetonitrile is ideally suited for chemical analysis, extractive purification, and organic and biochemical reactions. At 40 ppm, odor was detected, after which olfactory fatigue was noted. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 500 ppm. Ace acetic acid nitrile cyanomethane ethane nitrile ethyl nitrile methane carbonitrile methyl cyanide.
For example, acetonitrile is used as a solvent in the production of insulin and antibiotics and as a raw material in the production of naturally occurring pesticides. Methanol has been shown to produce fetotoxicity in the embryo or fetus of laboratory animals. Prenatal exposure to ethanol is associated with a distinct pattern of congenital malformations that have collectively been termed the fetal alcohol syndrome. If medical advice is needed, have product container or label at hand keep out of reach of children. Pierce lcms grade acetonitrile is specially purified and tested to the highest specifications to ensure the integrity of your data, maximize sensitivity in. Details of the supplier of the safety data sheet emergency telephone number chemtreco, inside the usa. Identification product identifier acetonitrile, distilled in glass other means of identification product code 1233 cas number 75058 synonyms ethane nitrile methyl cyanide cyanomethane professional, scientific and technical activities. Box 2650 tulsa, oklahoma 74101 for emergency source information contact. This chemical is on the special health hazard substance list.
Relevant identified uses of the substance or mixture and uses advised against. Acetonitrile by dupont dated 032802 original location. Acn, cyanomethane, ethanenitrile, ethyl nitrile, methyl cyanide, methanecarbonitrile recommended use. Acetonitrile is the chemical compound with the formula ch3cn. Hazardous in case of skin contact irritant, of eye contact irritant, of ingestion, of inhalation. Acetonitrile ch 3 cn, cas 75058, also known as methyl cyanide or cyanomethane, is the simplest organic nitrile. Acetonitrile safety data sheet according to federal register vol. Acetonitrile is a colorless liquid with an aromatic odor. It is produced mainly as a byproduct of acrylonitrile manufacture. Cyanobearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.
If inhaled if breathed in, move person into fresh air. Ph eur find msds or sds, a coa, data sheets and more information. Inhalation move casualty to fresh air and keep at rest. Show this safety data sheet to the doctor in attendance. This colourless liquid is the simplest organic nitrile hydrogen cyanide is a simpler nitrile, but the cyanide anion is not classed as organic. Acetonitrile is a common twocarbon building block in organic synthesis of many useful chemicals, including acetamidine hydrochloride, thiamine, and. Other information revision b, june 2015 the information contained herein is provided in good faith and is believed to be correct as of the date hereof. Acetonitrile page 2 of 6 determining your exposure read the product manufacturers material safety data sheet msds and the label to determine product. Safety data sheet sds acetonitrile, 15% solution 01. Acetonitrile is the most basic and simple organic nitrile. Acetonitrile is produced primarily as an acrylonitrile manufacture byproduct. Acetonitrile msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. Identification of the substancemixture and of the companyundertaking 1.
Certificate of analysis coa specification sheet pdf. Upload files that contain viruses, corrupted files, or any other similar software or. The revised idlh for acetonitrile is 500 ppm based on acute inhalation toxicity data in humans deichmann and gerarde 1969. May be harmful if swallowed, inhaled, or absorbed through the skin. Produced mainly as a byproduct of manufacturing acrylonitrile, acetonitrile is a colorless liquid with an etherlike odor. Page 1 of 7 msds acetonitrile material safety data sheet msds. Safety data sheet according to 29cfr19101200 and ghs rev. P280 wear eye protection, face protection, protective clothing, protective gloves. H373 may cause damage to organs through prolonged or repeated. It has also been detected in smoke from burning wood or other plants. Hazards identification potential acute health effects.
Acetonitrile is a nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group. This product is recommended for laboratory and manufacturing use only. Consider cyanide antidote as clinically indicated, such as sodium thiosulfate and sodium nitrate. Airgas usa, llc and its affiliates 259 north radnorchester road. Precautionary statements p264 wash contaminated skin thoroughly after handling. Ldlc50 values that are relevant for classification.
P271 use only outdoors or in a wellventilated area. This reagent is intended for nterminal protein sequencing applications. Upload files that contain software or other material protected by intellectual property laws or by rights of privacy of publicity unless you own or control the rights thereto or have received all necessary consents. In industry, it is likewise used as a solvent for the manufacture of such products as pharmaceuticals. Acetonitrile, one of the most potent known agonist of type 1 inositol 1,4,5trisphosphate receptor insp3 r.
In a wellconducted study in mice, the oral ld50 of acetonitrile was calculated to be 617 mgkg. Acetonitrile hplc, fisher chemical fisher scientific. Available in various grades, acetonitrile is commonly used in the laboratory. Material safety data sheet acetonitrile msds section 1.
Wear appropriate protective clothing to prevent skin exposure. Acetonitrile is an organic compound meaning its carbonbased with the chemical formula ch 3 cn, and is classified as a nitrile in terms of its functional group. Acetonitrile market global industry analysis, size and. Refer to special instructionsmaterial safety data sheets. Common name acetonitrile english name acetonitrile cas number 75058 molecular weight 41. Acrylic acid material safety data sheet cas no 79107. Ethanol solution is classified as dangerous goods according to the australian code for the transport of dangerous goods by road and rail. Incompatible materials strong oxidizing agents, strong acids, reducing agents, bases hazardous decomposition productshydrogen cyanide hydrocyanic acid, nitrogen oxides nox. First aid eye contact immediately flush with large amounts of water for at least 15. First aid measures description of necessary measures according to routes of exposure. If vomiting occurs naturally, rinse mouth and repeat administration of water. Three volunteers were exposed for 4 hours at 40, 80, or 160 ppm acetonitrile. Exposure to very high concentrations of acetonitrile can result in cyanide poisoning.
Risk phrases safety phrases r10 flammable r2022 harmful by inhalation and if swallowed. Identification of the substancemixture and of the companyundertaking. Find msds or sds, a coa, data sheets and more information. Safety data sheet bisacetonitriledichloropalladiumii. Acetonitrile 75058 100 toxicological data on ingredients. When acetonitrile and methanol are respectively mixed with water in the same ratio, the acetonitrile based solution generally has a higher elution strength. Acetone safety data sheet according to federal register vol. It has a role as a polar aprotic solvent and an ec 3. First aid measures general advice consult a physician. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. This colourless liquid is the simplest organic nitrile.
Calculate concentration, c, of acetonitrile in the air volume. A respiratory protection program that meets oshas 29 cfr 1910. Adg acetonitrile solution ab sciex australia pty ltd po box 514. Keep away from open flames, hot surfaces and sources of ignition. Sheet msds, available from ineos, for information on the chemical. Acetonitrile is a clear, colorless liquid with a sweet, ethereal odor. Cyanomethane, ethanenitrile, ethanoic acid nitrile, methane, cyano, methyl cyanide, methanecarbonitrile, acn meets acs specifications, meets reagent specifications for testing uspnf monographs. Acetonitrile is on the right to know hazardous substance list because it is cited by osha, acgih, dot, niosh, dep, nfpa and epa. Acetonitrile is the chemical compound with the formula ch 3 cn. Flammable in the presence of a source of ignition when the. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. Before handling, always consult a current materials safety data. Acetonitrile is used as a solvent and to make other chemicals, fibers, plastics, and in dyeing fabric.
Ethanol has been shown to produce fetotoxicity in the embryo or fetus of laboratory animals. Adg acetonitrile solution ab sciex australia pty ltd. Acetonitrile and acetonitrile solutions solvent by type. Material safety data sheet acetonitrile section 1 chemical product and company identification msds name.
Fire hazard, acute health hazard, chronic health hazard 16. Acetonitrile and acetonitrile solutions please visit the applications portal of the solvent center to ensure that you select the correct solvent grade for your application. Very toxic to aquatic life precautionary statements. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. It is also a hazardous chemical substance and regulated as such throughout most of the world. Hazards identification classification of the substance or mixture signal word. Wear appropriate protective gloves to prevent skin exposure. In particular, in some cases where the mixture ratio is low, the same retention times can be achieved using acetonitrile with less than half the ratio of methanol, as can be seen for. Firstaid measures eyes rinse with plenty of water for at least 15 minutes and seek medical attention immediately. Chemical product and company identification product name. Safety data sheet according to federal register vol. Acetonitrile breaks down slowly in the body to release the cyanide ion.
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